Background: Work design discusses a range of job features, extending from internal and external organizational features to the way responsibilities are systematized, that affect what staff nurses do at work engagement and how successfully they can achieve it. Aim of the study: Is to identify the relationship between work design characteristics and work engagement among staff nurses. Research design: A descriptive correlational design was used to carry out this study. Setting: The study was conducted at Ain Shams University hospital. Subjects: The study sample estimated to be (173).Tools: Data for this study were collected by using two tools namely: work design characteristics questionnaire and utrecht work engagement scale. Results: The findings revealed that more than one third of staff nurses (37.5%) had a moderate perception of work design characteristics and slightly less than half of staff nurses (48.6%) had high engagement level. Also, there was highly statistically significant positive correlation between total work design characteristics levels and their total work engagement among staff nurses. Conclusion: There was a highly statistically significant relationship between work design characteristics and work engagement among staff nurses. Recommendations: Nurses' managers should receive provide training courses about work design characteristics to support their staff nurses, Managers should constantly evaluate staff nurses engagement levels, develop strategies that encourage staff nurses to adopt good work engagement.