Aim: The aim of this study was to explore job stress and coping strategies and their relations to job satisfaction among Nursing Faculty Academic Staff.Methods: Descriptive correlational design was used. The setting was the Faculties of Nursing at the University of Menoufia, Tanta, Banha and Cairo, Egypt. Multistage random sampling technique was employed to select 200 nursing faculty academic staff. Tool1:  Faculty Stress Index (FSI). Tool2: Job Satisfaction Survey. Tool3: Coping Strategies Questionnaire. Results: The main findings of this study illustrated that the majority of faculty members under study were found to have a moderate level of job stress and low level of job satisfaction. Also, the most frequent coping strategies employed were prayer followed by spending time with family and relaxation. Also, the most frequent sources of stress were the dimensions of rewards & recognition and professional identity. Conclusion: There was a statistically significant negative correlation between all job stress dimensions and total job stress with job satisfaction. Levels of stress and satisfaction significantly differed according to the demographic characteristics of participants. Recommendations: Improving the living conditions for nursing faculty members and adopting of approved mechanism for incentives, rewards and promotions would be beneficial to minimize stress levels and improve the levels of job satisfaction.