Background: Vesicular mole is an abnormal condition where there is degeneration and changes in chorionic villi, endangering women's health by more severe complications. The study aimed to: to assess the nurses' knowledge regarding discharge care plan for women diagnosed with vesicular mole. Research design: Descriptive exploratory design was used to conduct the study. Setting: The study was conducted at all departments of Ain Shams university maternity hospital Sample: A convenient sample to recruit 200 nurses working at previously mentioned setting. Data collection: The first tool: structured interviewing questionnaire was used to assess nurses' general characteristics, Nurses' knowledge regarding vesicular mole and source of their knowledge Second tool: discharge care plan was used to assess nurses' knowledge regarding discharge care plan for women diagnosed with vesicular mole Results: Findings of the present study showed that 72% of the studied nurses had poor knowledge regarding vesicular mole, also 72% of them had their knowledge from study field, 67% of them had unsatisfactory knowledge regarding items of discharge care plan for women diagnosed with vesicular mole. Conclusion: The present study concluded that near to three quarters of study sample had poor knowledge regarding vesicular mole. Slightly more than two thirds of them had unsatisfactory knowledge regarding discharge care plan for women diagnosed with vesicular mole. Recommendation: Adding educational program regarding role of nurse in the participation in discharge care plan for women diagnosed with vesicular mole. Further research: Barriers of application of discharge planning process for women diagnosed with vesicular mole among maternity nurses.