Background: Osteoporosis (OP) is a crippling condition that often results in premature mortality and significant morbidity that is manifested in the form of fractures, bone deformity, impairments quality-of-life. Aim of the Study: to assess Knowledge, health belief, and self- efficacy for patients with osteoporosis. Design: A descriptive exploratory design was used in this study. Setting: The study was carried at outpatient osteoporosis clinics in Shebin Alkawm Teaching Hospital. Sample: Purposive sample of 100 adult patients from both gender were be required in this study. Study tools: The data for this study were collected by using three tools: Tool I structured interviewing questionnaire to gather data about patient's socio-demographic characteristics, medical history of the patients and their knowledge about osteoporosis.  Tool II: Osteoporosis health belief scale. Tool III: Osteoporosis self-efficacy scale. Results: there were highly statistical significance difference between total knowledge and total health belief. Also' there were statistical significant difference between total self-efficacy and total health belief as P value (0.000, 0.025) respectively. In addition to that there were no statistical significant difference between total knowledge and total self-efficacy as P value 0.830. Conclusion: less than three quarters of the studied patients had total unsatisfactory level of knowledge about osteoporosis, also less than three quarter of them had moderate health belief regarding osteoporosis. Additionally, more than half of them had low self-efficacy. Recommendations: Continuous health education programs about osteoporosis prevention are necessary to encourage health life style and healthy habits among patients with osteoporosis.