Background: Hyperemesis gravidarum is a severe complication of pregnancy characterized by prolonged and intense nausea and vomiting, leading to dehydration, malnutrition, and decreased quality of life for affected women. Aim: To assess the effect of prenatal education on knowledge, practices, and quality of life among pregnant women with hyperemesis gravidarum. Design: One-group, quasi-experimental pre- and post-test design. Setting: The study was carried out at two hospitals: Shebin El-Kom Teaching Hospital and Menoufia University Hospital, in the antenatal outpatient clinics and the department of obstetrics and gynecology (high-risk pregnant unit). Sample: A purposeful sample of 110 pregnant women experiencing hyperemesis gravidarum participated in the study. Tools: Data were collected using a modified 24-hour pregnancy-unique quantification of emesis (PUQE) questionnaire, a knowledge assessment sheet, a health practices evaluation sheet, a structured questionnaire, and a quality-of-life questionnaire. Results: The educational program significantly improved pregnant women's knowledge about hyperemesis gravidarum, with good knowledge scores increasing from 19.1% to 86.4% for concepts of HG, 0% to 70% for causes and risk factors, and 0% to 81.8% for signs and symptoms. The overall practice score for hyperemesis gravidarum before 2.7% and after the educational program was 87.3% of the participants had satisfactory practice. Additionally, there was a significant reduction in the severity of hyperemesis gravidarum symptoms (p < 0.05). Participants reported positive impacts on their quality of life following the educational sessions. Conclusion: Prenatal education sessions significantly enhanced pregnant women's knowledge. Participants reported positive impacts on their quality of life following the educational sessions, which promoted healthier practices and mitigated the severity of hyperemesis gravidarum symptoms. These findings underscore the importance of educational interventions for improving outcomes for women with this challenging condition. Recommendations: The dissemination of these findings advocates for the implementation of structured prenatal education sessions targeting pregnant women with hyperemesis gravidarum to optimize care and enhance their quality of life.