Background: Amputation is known as a triple insult since it causes loss of function, sensation, and alteration in body image. This abrupt transformation affects the individual's self-esteem and quality of life due to physical activity restrictions immediately following amputation. Aim of the study: was to evaluate the effect of a self-compassion training program on self-esteem and quality of life among patients with post diabetic foot amputation. Research design: Quasi-experimental research design, pre-posttest was conducted. Setting: The study was conducted at the Surgical Outpatient Clinic of Benha University Hospital. Subject: A purposive sample of (60) patients with post-foot amputation was chosen. Tools of data collection: I: Interviewing questionnaire, II: Self-compassion scale, III: Self-esteem Scale, IV: Quality of Life Scale. Results: The main findings of the study were: less than two third of the studied patients had high level of self-compassion post program, nearly two third of them had moderate level of self-esteem and average level of quality of life post program implementation. There was a highly statistically significant positive correlation between total mean score of self-compassion, self-esteem and quality of life among studied patients following program implementation. Conclusion: The self-compassion program applied in the current study has the potential to dramatically increase self-compassion, self-esteem, and quality of life in patients with post-diabetic foot amputations. Recommendations: As a consequence of the favorable impacts of the self-compassion training program, it is advised that the same protocol be incorporated into the rehabilitation process for elderly patients with foot amputation. A further study should demonstrate such a training program in various settings and with a large number of amputee-elderly patients.