Background: Leader member exchange is the quality of the exchange relationship between supervisor and the nurses of an agency. This relation had its outcome in staff and organization. Aim: This study aimed to assess the Influence of leader member exchange on Job Involvement among staff nurses. Research design: A descriptive correlational design was used in this study. Setting: The study was conducted in cardiovascular hospital, which affiliated to Ain-Shams University Hospitals. Subjects: The study sample consisted of 119 staff nurses.  Tools of data collection: Data were collected by using two tools namely; Leader Member Exchange Survey and Job involvement Scale. Results: Displays that, more than one quarter of the studied staff nurses had high total perception level regarding leader member exchange while, more than half of them had moderate level of Job involvement. Conclusion: there was highly statistically significant positive correlation between total studied staff nurses' perception regarding leader member exchange and their total job involvement level. Recommendation: Enhance mutual relationship between leader and member which help them to express their feeling and introduce their work problem and share in solving it.