Background: Organizational change is an important phenomenon experienced in most work settings, such as health care, nursing sectors, military, and manufacturing, banking, and higher learning institutions. Aim: the study aimed to assess the relationship between readiness for change and organizational commitment among staff nurses. Design: A descriptive correlational design was used. Setting: The study was conducted at ain shams university hospital which affiliated to ain shams university hospitals. Subjects: A simple random sampling technique was used to select 165 out of 280 staff nurses. Data collection tools: Data were collected by using two tools namely;  the readiness for change questionnaire and organizational commitment scale Results: The current study find readiness to change among the studied staff nurses in the study sample shows that, more than two thirds of the studied nurses (73.30% & 67.30%) had high change efficacy and appropriateness of change respectively. Also, more than half of them (53.3%) had low level of managerial support. In addition, more than two thirds of them (69.1%) had low level of personally beneficial and more than half of them (51.5%) had high level of readiness to change. Conclusion: there was high statistically significant positive correlation between readiness to change and appropriateness of change and personally beneficial. Recommendations: Provide effective and continuous training programs for nursing staff based on needs assessment to develop their readiness to change. Further research is proposed to assess the effect of educational program for nurses about organizational commitment on nurse's staff readiness to change.