Background: Pressure injury has a significant danger among immobilized patients with orthopedic disorders and consider a clinical challenge for nurses and other healthcare professionals globally. Aim: to determine the effect of nurse driven skin care bundle on hospital acquired pressure injury among immobilized patients with orthopedic disorders. Design: A quasi-experimental design, two groups(study/control) was used. Setting: The study was conducted in the orthopedic department at Menoufia University Hospital. Subjects: A consecutive sample of 118 immobilized adult patients of both genders. Instruments: Instrument I: Structured Interview questionnaire, Instrument II: Comprehensive skin assessment observation checklist, Instrument III: Braden Risk Assessment Scale. Results: It was described that 49.2% of the study group and 35.6% of the control group was in the category of age between 50 < 60 years old and around half of both study and control groups (50.8% and 54.2% respectively) was male. There was a significant statistical difference between the study and the control group related to the occurrence of hospital acquired pressure injury post intervention with (p<0.001). Conclusion: a nurse driven skin care bundle had a positive significant effect on preventing hospital acquired pressure injury among immobilized patients with orthopedic disorders. Recommendations: patients with orthopedic disorders should be oriented to identifying and reporting any changes in their skin condition. Collaborating with other institutions to implement nurse driven skin care bundle as a preventive measure to reduce the incidence of hospital acquired pressure injury among immobilized patients with orthopedic disorders.