Context: Job crafting is a phenomenon of modifying tasks to improve productivity, enable employee to develop new skills, fellow innovative behavior, and independence in doing responsibilities, Aim: The aim of the study to assess job crafting and its relation to innovative behavior and job autonomy among staff nurses. Methods: Design: A descriptive correlational design was employed to carry out this study. Setting: Cardiovascular Surgery Hospital, which affiliated with Ain Shams University Hospitals. Subjects: All staff nurses working in the specified study setting, their total number are 119. Tools: Three tools were utilized namely Job Crafting Scale, Innovative Behavior Scale, and Job Autonomy Scale. Findings: display that 70.6% of the studied staff nurses perceived a high level of total job crafting, and 80.6% of them had a high level of total innovative behavior. Additionally, 63.9% of them had a high level of total job autonomy. Conclusion: A high statistically significant positive correlation was presented between staff nurses' perception of total job crafting, innovative behavior, and job autonomy.  Recommendations: Nurse managers encourage nurses to design their jobs through training and feedback on job crafting behavior. As well as inspiring staff nurses to grow personally by offering them a chance to learn about novel innovations and a variety of work assignments.