Background: Angina is a serious health condition, with a wide range of patients' symptoms which add extra burdens to their health. Providing nursing guidelines reduces symptoms burden and improves the patients' quality of life. This study aimed to evaluate effect of nursing intervention guidelines on symptom burden among patients with angina. Materials and methods: A quasi-experimental design was used. A convenience sample of 100 patients with angina in the outpatient cardiac clinic unit at Suez Canal University Hospital, 50 patients for the study group and 50 patients for the control group. Data were collected using a patient demographic and medical information questionnaire and the angina symptom questionnaire (ASQ). Results: The study group exhibited significant decreases in comparison to the control group for all parameters evaluated, with significant effect sizes (η2 ranging from .38 to .44, p <0.001. The total symptom burden scores of the study and control groups indicate a statistically significant reduction within the study group. Post-intervention and follow-up scores showed statistical differences. In comparison to the control group (Post: 28.54 ± 6.30; Follow-up: 26.62 ± 4.81), the study group showed significantly lower scores at follow-up (9.72 ± 1.33) and post-intervention (14.12 ± 3.46) with very significant p-values (both p <.001). The observed differences had significant effect sizes (Post: d = 2.8; Follow-up: d = 4.8, η2 =.63). Sizes (η2 ranging from .38 to .44, p <.001). Conclusion: There was a statistically significant difference between the study and control group regarding symptom burden after implementation of intervention nursing guidelines. Recommendations: Intervention guidelines should be conducted for Angina patients as they are the key to reducing symptom burden.