Background: Chronic kidney disease (CKD) is a chronic decrease in kidney function that causes permanent and advanced kidney tissue impairment. Blood pressure is a major factor that could cause death up to 20 times among patients with CKD undergoing hemodialysis. Aim: To evaluate the impact of pedaling exercise on blood pressure among patients with chronic kidney disease maintained on hemodialysis. Research design:  Quasi-experimental one group pre-post design was used. Study Setting: This study was conducted in hemodialysis unit at kafrelsheikh University Hospital. Study sample: A convenience sample of 54 patients with CKD Maintained on Hemodialysis three times / week. Tools: One tool for data collection was used in this study divided into three parts as follow: part (I) structured interview questionnaire, part (II) included medical data, comorbidities and exercise regimen and part (III) included blood pressure measurement follow up sheet. Results: the results showed significant decrease in in blood pressure measurements among the studied group. one way ANOVA test showed a statistical difference between total blood pressure mean scores in relation to time of intervention (preintervention, one week post postintervention , six weeks  and 12 weeks later) as Mean ±SD = (138.7±10.9, 132.7 ±10.8 , 123.2 ±10.9, &112.5 ±11.3) and (F= 53.344&p= <0.001) in systolic blood pressure respectively and Mean ±SD = (90.3 ±6.9, 84.5 ±6.5, 80.1 ±5.3 &75.7 ±4.5) and (F= 56.698&p=<0.001) in diastolic blood pressure consequently. Conclusion: pedaling exercise can lower blood pressure among patients with CKD undergoing hemodialysis therapy. Recommendations: Nurses educate patients to use save nonpharmacological measures as pedaling exercise to decrease blood pressure among patients with CKD on hemodialysis.