Background: Climate change is used to describe the gradual rise in global temperatures that is mostly accelerated by human activities and can cause serious impact on human health. Human daily living activities are result in different gases into atmosphere. University students' coping with climate change specifically nursing students is expected to be one of the important indicators to the attitudes of the general population. Aim:  The study aimed to evaluate the effect of coping strategies on nursing students' daily living activities and attitude regarding climate change. Subject and Methods: This study was a quasi-experimental research design Sampling: A purposive sample was selected while this study was performed on 254 nursing students at Faculty of Nursing, Helwan University and data were collected using 1) Structured Interviewing Questionnaire Sheet, 2) Students' Daily Living Activities Questionnaire Sheet, 3) Students' Attitude regarding climate change Questionnaire Sheet and 4) Coping Scale with climate change Results: The main results showed that there was a statistically significant positive correlation between students' coping with climate change and their knowledge, daily living activities and attitude post coping strategies implementation. Conclusion: the study concluded that implementation of the coping strategies had a positive change on the nursing students' daily living activities and attitude regarding climate change. Recommendations: This study recommended that implementing continuous programs for coping with climate change, integrating climate change coping strategies into the nursing curriculum and the further research should be done with a larger sample size in a several and broader geographical area.