Background: Fostering creativity and adaptation in a healthcare setting is linked to ambidextrous leadership. Educators who support inquiry can assist nurses in acquiring the skills necessary to accept change, integrate new technology, and apply creative methods to patient care. The aim of the study:  To identify the relationship between ambidextrous leadership behavior and career competencies among nurses. Subject and method: A descriptive correlational study design that had been used. Setting: Minia General Hospital served as the study's site. Subject: The current study's convenience sample consisted of all 331 staff nurses at Minia General Hospital. Tools of data collection: 1^st tool: Demographic data sheet, 2^nd tool: Ambidextrous leadership behavior scale, and 3^rd tool: Nurse Career Competence Questionnaire. Results: (58.3) percent of Minia general hospital nurses exhibited "moderate" responses toward ambidextrous leadership behavior. In addition, (57.7) percent of nurses exhibited "moderate" responses toward career competencies. Conclusion: There was a positive correlation between ambidextrous leadership behavior and career competencies. Recommendations: Programs for developing leaders that concentrate on ambidextrous leadership should be supported by healthcare organizations.