Background: chronic obstractive pulmonary disease (COPD) is a chronic pulmonary disorder that is characterized by progressive and partially reversible airflow limitation. The natural history of COPD is punctuated by recurrent episodes of acute exacerbations, which often require hospitalization and negatively affect patients' quality of life. Aim: the aim of study was to Assess quality of life for patients with chronic obstructive pulmonary disease in outpatients clinic at Beni-Suef University Hospital. Subjects and methods: this study was Descriptive study, Sample: A purposive sample was selected and this study was performed on 100 patients, Setting: Outpatients clinic at Beni-Suef University Hospital Tool:Two tool was used to collect data., Tool (I): Structured interviewing questionnaire and it was consisted of three Tool II. Quality of life questionnaire for COPD. Results: • More than one third (37%) of the studied patients are 50<60 years old with Mean/ +-SD 2.77+- .1033 years. All (100%) of them studied patients have previous hospitalization. • Vast majority of the sample (90%) has unsatisfactory knowledge about COPD disease. Majority (87%) of the studied patients has inadequate level of total QOL. Conclusions: The knowledge of the studied patients was unsatisfactory and the QOL of them was inadequate regarding COPD. Recommendations: Continuous educational program for patients with COPD and their family about COPD management, complication and ways of prevention.