Background: Uses of quick response codes in medical education were largely aligned to different themes. These themes involved enhancing member involvement, simulation training, and just-in-time learning.  Aim: To determine impact of quick response code training on clinical competency and perception among first year nursing students. Design: A quasi-experimental design (study-control) was used. Setting: The study was conducted at clinical laboratory skills and the lecture hall for the first year nursing students in Faculty of Nursing-Menoufia University. Subjects: A convenient sample of 640 first year nursing students who were enrolled in first semester of Fundamental nursing course in 2022-2023. Tools: four tools were utilized (1) structural interviewing questionnaire, (2) Nursing students' knowledge sheet, (3) students' perception of QR code learning, and (4) observational checklist using competency. Results: 0.3% and 1.2% of study and control groups respectively had good knowledge level at pre QR code training that were highly significantly improved among study group to 86.6% compared to 9.4% of control group post QR code training. Also; there were significant improvement of the mean scores of perception and clinical competency level of vital signs among study group compared to control group post QR code training. Conclusion: there was a significant improvement of knowledge level about QR code learning, students' perception of using QR Code in their studying activities and they had more competent performance after QR code training. Recommendations: Developing QR codes for different units of nursing curriculum to make learning more expressive, interesting and less time consuming as well as replication of the study on other activities using greater sample to allow for generalizability of results.