Background: Deep Vein thrombosis (DVT) is thrombophlebitis of deep veins and is known to be associated with fatal complications. The use of appropriate measures through risk assessment is of vital importance in preventing DVT-related complications. Well's criteria are a beneficial tool in categorizing the patients and, therefore may guide in using appropriate preventive strategies and promoting the well-being of immobilized patients. The present study aimed to evaluate the effect of educational program regarding risk assessment and preventive strategies among orthopedic surgical patients with deep vein thrombosis. Research design: This study used a quasi-experimental research design. Setting: The study was carried out in the orthopedic department and orthopedic outpatient clinic at Qena General Hospital. Subjects: The samples were selected by a convenient sampling technique of all orthopedic surgical patients with deep vein thrombosis admitted to the above-mentioned settings at the time of data collection. Tools: Three tools were used for data collection of this study: Tool I: Structure interview Sheet, Tool II: Observational checklist, and Tool III - Observational checklist for preventive strategies were used. Results: The findings of the study revealed that there were highly significant improvements in patient's knowledge regarding deep vein thrombosis post-educational program implementation (P=0.005). Statistical highly significant differences and reductions were detected between orthopedic surgical patients with deep vein thrombosis post-educational program implementation regarding risk assessment and preventive strategies. Conclusion: The educational program implementation had a significant positive effect on reducing risk assessment and preventing deep vein thrombosis among orthopedic surgical patients. Recommendations: The educational program regarding deep vein thrombosis prevention should be conducted and integrated into the rehabilitation programs. Provide the patients with booklets and illustrated pamphlets for each to improve their information and reduce their risk for deep vein thrombosis.