Background: Antibiotic self medication is global health issue and associated with many complications. Nursing students are susceptible to self medication on the account of handling and having access to different types of antibiotics in their future practice. Aimof The study: Assess knowledge and reported practices of nursing students regarding risks of antibiotics self-medication. Research Design: A descriptive research design was applied in this study. Sample: Simple random sample was equal 222 nursing students at first year in Faculty of Nursing at Beni suef city. Setting: Faculty of Nursing in Beni Suef city, Egypt.Tools: One tool used to achieve the aim of this study: Interviewing Questionnaire Sheet which consisted of three parts to assess personnel characteristics, knowledge about risks of antibiotics self-medication, reported practices of antibiotics self-medication. Results: The study showed that, 52.3% of the studied students had a fair level of knowledge regarding effective using of antibiotic, 48.2% of the studied students had a satisfactory level of self-reported practice about risks for using antibiotics. Conclusion: There was a highly significant association between studied student knowledge and self-reported practice scores regarding risks of antibiotics self- medication. Recommendations: further research about a health education program to increase awareness about the use of medicines among nursing student and to enable them to make the right decisions relating to health problems.