Background: Bronchial asthma is one of the most common chronic diseases among children and adolescents. Parents have an essential role in management of children's with asthma. Therefore, mothers should gain large knowledge that enable them to identifying the risk factor particular for each child and bypass them as a strategy for secondary prevention to control asthma attacks. The aim of the study: to evaluate the effect of the educational program based on PRECEDE – PROCEED model application on mothers 'performance regarding care of their children with asthma. Research design:  A quasi-experimental (pre/post-test) design. Setting: The current study was conducted in Pediatric Medical Departments at Benha University Hospital. Tools of data collection: Tool (I): A structured interview Precede questionnaire sheet.  This instrument was divided into four parts: Part (1): Personal characteristics of the mothers, part (2): Characteristic of the children, part (3): Medical history of studied children and part (4): Asthma characteristics of the studied children and their sensitivity. Tool (II): Assessment sheet for predisposing factors. It was divided into three parts. Part (1):  Mothers' knowledge about asthma and its treatment, part (2): Mothers' reported practice regarding care of children with asthma, part (3): Mothers' attitude toward children with asthma.  Tool (III):  Reinforcement factors assessment Sheet. Tool (IV):  Enabling factors assessment Sheet.  Results: there was a highly statistically significant positive correlation between total mothers' knowledge, reported practice, reinforcing, enabling factors, and attitude according to care of their children suffering from bronchial asthma thorough Precede Proceed phases (P < 0.001).  Conclusion: Based on the result of the current study, it was concluded that, the educational program based on PRECEDE-PROCEED Model is an effective method in planning and providing health education to improve mothers' knowledge, reported practices and attitudes regarding care of their children with asthma and promoting enabling and reinforcing factors that support prevention and control  trigger of asthma among them. Recommendation: Educational training programs about asthma should be conducted at primary health care settings and hospitals for parents to understand and know how to deal with asthma as a chronic disease in order to overcome challenges of asthma control.