Background: A typical bothersome symptom of upper respiratory tract infections (URTI) in children is nocturnal cough, which can influence how well kids sleep. Therefore, thyme is a herb that contains compounds that are antioxidant and reduce coughing. Coughs have long been treated naturally with honey. Objectives: to evaluate the impact of thyme drink with honey on nocturnal cough and sleep quality for children. Research design: In the current research, a quasi-experimental approach was used. Subjects: Purposive sample including (300) children their mothers. Setting: This research was carried out at the pediatric medical department at Minia University Hospital for Obstetrics and Pediatrics (MUHOP) and Minia General Hospital (MGH). Tool: one tool was utilize to collect the important information such as; 1) assessment of children nocturnal cough symptoms, severity, as well as sleep quality pre and after thyme drink with honey administration. Results: showed that there was remarkable improvement of children's sleep quality, decreased cough frequency, and severity, after 3days of utilize thyme drink with honey. So, the mothers satisfaction rates, and the intention to use thyme drink with honey in future attacks were significantly in both hospital MUHOP, and MGH (p=0.02, and 0,03); respectively. Conclusion: Thyme drink with honey can enhance children's severity of nocturnal cough, frequency, and sleep quality in both hospitals (MUHOP, MGH). Recommendations: The researchers should be continuous developing further studies to evidence the impact of Thyme drink with honey on children who have nocturnal cough.