Background: Inflammatory bowel diseases [IBDs] are chronic inflammatory disorders that affect adversely on various aspects of daily life. Therefore, a protocol of nursing care is crucial, taking into account IBD-related disability and over all daily-life burden. Aim of the study: This study aimed to evaluate the effect of implementing a protocol of nursing care on daily life burden of patients with inflammatory bowel diseases. Design and Setting: The present study applied a quasi-experimental research design. The study was operated in Outpatient Rheumatology Clinic at Damanhour National Medical Institute in Elbehira governorate, Egypt. Subjects: A purposive sample of 70 adult patients admitted to the above-stated settings. The study subjects were divided randomly into two equal groups; study and control; each group comprised of (35) patients. Tools: two tools were used for data collection, Tool I: The inflammatory bowel disease patient's socio demographic &clinical data assessment schedule, Tool II: The inflammatory bowel disease disk (IBDD). Results: it was observed that, there was a extremely statistically significant difference related to levels of their daily life burden pre and post-2 weeks of implementation of a care protocol, compared to the control group. Conclusion and Recommendation: Protocol of nursing care of patients with IBD had a crucial role in improving patients' compliance with therapeutic regimen which affects positively their daily life burden related disabilities. Also, it was recommended that pre-service training instructions should be supplied to the newly assigned nurses before undertaking autonomous responsibilities for IBD patients' care. In addition, established competencies fliers about care for IBD patients would be accessible to all staff nurses in medical departments and outpatient clinics.