Background: Simulation-based training has gained popularity in nursing education as a safe and effective method for improving students' clinical skills. Aims: This study aims to conduct a systematic review of the available literature to evaluate the effectiveness of simulation-based teaching in nursing education. Methods: A systematic review of the literature was conducted using electronic databases, including Web of Science, PubMed, CINAHL, MEDLINE, Scopus, and Cochrane Library. The search strategy included keywords such as "simulation-based teaching," "nursing," and "learning." The review included 15 studies conducted in various settings that were published between 2010 and 2023. The inclusion criteria for researched literature focused on simulation-based teaching, and the exclusion criteria included studies that did not involve nursing students as participants. Results: Simulation-based teaching was found to be effective in enhancing nursing students' clinical skills, knowledge, and reasoning abilities, as well as improving clinical decision-making and patient outcomes. Conclusion: The systematic review indicates that simulation-based teaching is effective in nursing education. However, there are still concerns about the optimal implementation and cost-effectiveness of simulation-based training. Additional research is needed to identify the most effective approaches and evaluate their efficacy in diverse settings. Recommendations: The study recommends further exploration and evaluation of optimal implementation and cost-effectiveness of simulation-based training in nursing education. Future research should identify effective approaches and assess their efficacy in diverse settings.