Background: Patients on hemodialysis struggle greatly with self-care. Patients' ability to regulate and manage their symptoms is necessary for improved self-care. Education can help to improve one's behaviors regarding self-care. Aim: Evaluate the effect of educational intervention on self-care behaviors of hemodialysis patients based on PRECEDE Model. Design: A quasi-experimental design was utilized. Setting: The study was carried out in the Dialysis Unit at Benha University hospital, in Benha City. Sampling: Purposive sample included 120 hemodialysis patients. Tools: Two tools were used for data collection, Tool I: A structured interviewing questionnaire to assess socio-demographic characteristics and medical history of the studied patients. Tool II: Predisposing, Enabling, and Reinforcing Questionnaires (PRECEDE Model questionnaire). Results: There was a significant statistically differences between hemodialysis patients' total predisposing and their enabling and reinforcing factors pre and post intervention implementation (P= 0.000). Conclusion: Health educational intervention based on PRECEDE model is effective in raising the level of self-care behaviors of hemodialysis patients. Recommendations: Provide continuous and repeated educational program for hemodialysis patients to assure they have sufficient level of knowledge and self-care.