Background: Self-care is described as the healthcare and social-care services provided to individuals to enable them to take better care of themselves. In Asthma, patient self-management programs incorporating multicomponent interventions such as self-management education, exercise training and psychosocial support can improve health outcomes and reduce healthcare costs. Aim: Evaluate the effect of training program regarding self-care practices and knowledge of bronchial asthma patients. Subjects and method: Design: A purposive sample of 70 adult patients diagnosed with Asthma included in this study.  Quasi experimental research design was used to conduct this study. Setting: Study was conducted in inpatient departments at Zigzag Chest Hospital and Chest Department affiliated to Zigzag University Hospital. The two settings affiliated to Sharkia Governorate, Egypt. Tools: Three tools used to conduct the study questionnaire about socio demographic characteristics, a standardized structured asthma knowledge questionnaire, regarding inhaled medications, a performance check-list adapted for each inhaler device, Nebulizer & breathing retraining Diaphragmatic Breathing and Cough Exercise. Results: The results revealed that there was a statistically significant difference between patients' knowledge of asthma self-management, accuracy of inhaler use technique and asthma control before and after the training program where P < 0.0001. There was a significant statistical improvement in patients' knowledge about asthma. It increased from 4.3% before the training program to 77.1% after the training program, and showed that there was statistical improvement asthma regarding the practice of the inhaler medication from 17.1% to 80% after the training program, showed that there was a statistically significant level of patients' knowledge about asthma regarding the practice of inhalation technique, it increased from 12.9% before the training program to 44.3% after the training program (p<0.05 Conclusion: Based upon the results of this study, it could be concluded that implementation of training program had a positive effect on improvement of the patients' knowledge, self care practices. post program implementation compared to pre-program implementation. Recommendations:  Promotion and enhancement of the self-care management to the patient through showing a picture about triggers, allowed foods, and follow up should be continued after termination of the treatment through the rehabilitation program.