Background:Deep venous thrombosis (DVT) is a major prevalent problem for orthopedic surgery patients. The Autar DVT scale can be used to quantify the risk of developing DVT and reduce post-operative complications. Aim: The study aimed to investigate theAutar scale-based nursing intervention efficacy on reducing the incidence of deep vein thrombosis among orthopedic surgery patients. Design: This study used a quasi-experimental research design (study and control group). Sample: A purposive sample of 100 adult patients with lower extremities orthopedic surgery. Setting: The research was conducted at the Mansoura University Hospital's orthopedic inpatient departments. Tools: Two tools were used, Tool I: Patient's DVT Assessment Sheetand Tool II: The Autarscale. Result: The DVT incidence rate on the third postoperative day in the study group was lower than that of the control group with a statistically significant difference (p < 0.05).Conclusion:Nursing intervention based on the Autar scale has a positive effect on reducing the incidence of deep vein thrombosis among orthopedic surgery patients. Recommendation: The Autar scale can be used in conjunction with enhanced nursing interventions and preventative measures to obtain the best predictive effects as revealed in this study, increase work efficiency, and reduce the occurrence of DVT.