Background: Cervical cancer is a public health problem contributing to high levels of cancer morbidity and mortality among women. Aim: the aim of the current study is to evaluate the effect of educational program based on the prevention model on women knowledge regarding cervical cancer. Methods: A quasi-experimental design (one group pre / post-test) was utilized. Sample: A convenience sample of 150 women were recruited for the current study. Setting: The study was conducted at Obstetric outpatient clinics affiliated to Kasr El-Ainy hospitals, which is a Cairo University from December 2022 to May 2023. Tool: Using Knowledge in Cervical Cancer and Prevention Methods 55-items Structured interviewing questionnaire Results: After implementation of the educational program, the satisfactory level of the total knowledge scores increased from 34% in the pre-test to 86% in the post-test. This improvement was maintained during the follow-up assessment with 77.3% with statistically significant differences (P<0.001(. Conclusion: The educational program, based on the preventative model was successful in enhancing women's knowledge about cervical cancer prevention. Recommendations: Empower the community health and obstetric nurses to implement the educational program to increase women's awareness regarding cervical cancer prevention in various healthcare settings. Health authorities should set up widespread screening initiatives, offer education, stimulate public knowledge through awareness campaigns, and remove obstacles to HPV vaccination to enhance cervical cancer prevention.