Background: Sepsis is a life-threatening organ dysfunction with high morbidity and mortality caused by impaired regulation of host response to infection. Because there is no confirmatory diagnostic test, the inpatients who develop sepsis may have delays in evaluation, testing, and treatment. Sepsis screening tools and interventional protocols based on standard criteria can provide a rapid method to identify sepsis and patients at risk for sepsis and organ dysfunction. Aim: Suggest sepsis interventional protocol for patients post-surgery. Design: A descriptive exploratory design was used. Setting: The study was carried in surgery and emergency intensive care units at Ain Shams University hospital. Subjects: A convenient sample consisted of all the health team (nurses and physician) and a purposive sample of adult patients from both gender in previous mentioned setting within 3 months. Tools: Two tools were used to collect data; Health team′ Self-administered questionnaire and Sepsis Screening Tool Results:  showed that 53% of the studied patients had sepsis and 29% of them were had sever sepsis. In addition, there were no statistically significant differences between health team opinion in surgery and emergency intensive care units regarding factors associated with sepsis rate among studied patients P ˃ 0.05 with a positive correlation between total sepsis rate and total score of factors associated with sepsis rate among patients' post-surgery in ICU surgery and ICU emergency   Conclusion: showed that half of the studied patients had sepsis and one third of them were sever sepsis. In addition, there were no statistically significant differences between health team opinion in surgery and emergency intensive care units regarding factors associated with sepsis rate among studied patients with a positive correlation between total sepsis rate and total score of factors associated with sepsis rate among patients' post-surgery in ICU surgery and ICU emergency. Recommendation: Provide periodic in-service training based on best practice guidelines for health team who work in intensive care units and emergency units regarding early detection of sepsis and organ dysfunction.