Background: Esophageal varices are one of the most significant comorbidity-related complications of liver cirrhosis. Patients with esophageal varices reported unsatisfactory levels of knowledge and fatigue, as well as recurrent hospital readmissions. The aim: The study aimed to assess the efficacy of the educational bundle on patients' clinical outcomes post-esophageal varices treatment. Setting: This study was done in the Gastroenterology and Hepatology department at Specialised Medical Hospital. Research design: This research employed a quasi-experimental design. Sampling: A purposive sample of one hundred patients with esophageal varices was recruited. Tools: This study utilized three tools to acquire relevant data. Tool I was the patients' assessment questionnaire, Tool II was the patients' knowledge questionnaire, and Tool III was the modified fatigue impact scale. Results: The current study showed that after using the educational bundle, 46% of the study group and only 2% of the control group had a satisfactory knowledge level, showing a statistically significant difference (p=0.007) between the two groups. Moreover, after two weeks of receiving the educational bundle, 94% of the study group and 80% of the control group had mild fatigue levels, showing a statistically significant difference. Regarding the readmission rate, there was a highly statistically significant difference between the two groups after three months of implementing the educational bundle. Conclusion: The educational bundle significantly improved the clinical outcomes of the study groups' post-esophageal treatment in knowledge, fatigue levels and hospital readmission. Recommendations: Patients with esophageal varices should receive the educational bundle as standard treatment.