Background: Cervical cancer is treatable type of cancer, especially when detected early and managed effectively. Despite this, half of women diagnosed with cervical cancer experience problems with sexual function. Aim: The aim of the study was to evaluate the effect of Roy adaption model on sexual function and pain coping strategies among women with early-stage of cervical cancer. Design: This study was conducted as quasi-experimental design. Setting: This study was conducted at Benha University Hospitals in Benha, Egypt, at the gynaecological inpatient unit and the outpatient clinics. Sampling: A Purposive sample included 68 women was used. Tools:  four tools were used for data collection including a structured interviewing questionnaire (demographic data and knowledge sheet), Roy adaptation model scale, coping strategies questionnaire, and female sexual function index. Results: Through all programme phases, the control group did not show any statistically significant positive association between total RAM and the total of other variables. Although there was a strong association between total RAM and total (knowledge, coping mechanisms, and sexual function) in the study group after three and six months of program application. Conclusion: The use of a nursing strategy based on Roy's Adaptation Model enhanced sexual function and pain coping strategies among women with early stage of cervical cancer. Recommendation: Provide instructional guidelines for women with cervical cancer to promote adaptation to sexual issues.