Abstract: It is becoming increasingly recognized that HCWs, especially nurses, who are critical to the delivery of safe and effective care in Intensive Care Units (ICUs), are exposed to a variety of occupational work-related safety hazards, as well as strategies to avoid these hazards, to maintain their health and wellbeing. Aim: to develop an occupational work-related safety guideline at general ICUs at EL-Beheira governorate. Methods: a methodological qualitative research design was utilized at all general ICUs affiliated to the Ministry of Health and Population (MOHP), at El-Beheira Governorate (n=13). Subjects: two groups: nurses (n=539) divided into head nurses (n=26) and nurses (n=513); and panel of experts (n=40), who were divided into academic experts (n=10) and professional experts (n=30). Tools: two tools were used Occupational Work-related Hazards Questionnaire (OWHQ) developed by the researcher and used by nurses to identify OWSH at general ICUs, and Appraisal of Guidelines for Research & Evaluation (AGREE II) Questionnaire, developed by Brouwers et al. and completed by academic and professional/clinical to validate the developed guideline. Results: more than one- half of nurses got moderate level of total OWSH mean percent score. Biological hazards was the first; followed by ergonomic, chemical, psychosocial and; lastly, physical hazards. However, the majority of strategies or recommendations to deal with these hazards got moderate scores. Conclusion: both academic and professional experts agreed upon the content and face validity, clarity, and quality of the developed occupational work-related safety guideline to be used by nurses at general ICUs. Recommendations: implementing the developed Occupational Work-related Safety guideline for nurses working at general ICUs to enhance their safety and conduct training programs and awareness sessions for the developed guideline