Background: Chemotherapy-Induced Nausea and Vomiting is one of the most common side effects in pediatric patients undergoing chemotherapy despite the development of antiemetics, so assessing nurses for knowledge and skills about chemotherapy-induced nausea and vomiting management is very important. Acupressure technique is one of non-pharmacological management approaches that control chemotherapy-induced nausea and vomiting among children with cancer. Aim: Assess nurse's performance regarding application of acupressure technique for children undergoing chemotherapy. Design: Descriptive exploratory design. Settings: The current study was conducted at National Cancer Institute and Dar-Elssalam Hospital which affiliated to Cairo University Hospital. Subject: A convenience sample composed of 36 nurses giving care for children with cancer and undergoing chemotherapy. Tools: Three tools were used for data collection; First tool: Structure questionnaire format. Second tool: Observational checklists for application of acupressure. Third tool: Attitude assessment scale. Results: The current study revealed that the mean age of the studied nurses was 29.7± 8.4 years, three quarters of them were males, the majority of the studied nurses were graduated from technical nursing institute, and about three-quarters of the studied nurses had poor level of knowledge about chemotherapy-induced nausea and vomiting and acupressure technique and all of them had incompetent level of practice regarding application of acupressure technique and had a negative attitude toward acupressure technique. Conclusion: The current study concluded that more than two-thirds of studied nurses had a poor level of knowledge related to chemotherapy-induced nausea and vomiting, and, the majority of them had poor level of knowledge regarding application of acupressure as well as all of them were incompetent in their practice level regarding application of acupressure technique. Recommendation: Periodical implementation of educational programs for all oncology nurses to improve their performance about non-pharmacological management of chemotherapy-induced nausea and vomiting