Background: Primary Nephrotic Syndrome is a worldwide epidemic in pediatric
nephrology. This study aimed to evaluate the impact of health instructions on
knowledge and reported practice of mothers' having children newly diagnosed with
nephrotic syndrome. Subject and method: A quasi-experimental (pre–post) research
design and carried out in the urologic pediatric outpatient clinic at Pediatric Minia
university hospital. Also, a purposive sample of eighty-five mothers who had children
newly diagnosed with nephrotic syndrome. Two tools were used in this study to
collect data: Tool I: Children and mothers' demographic characteristics, present the
child's medical history, and mothers' knowledge level. tool II: mothers' reported
practices. Results: the studied mothers having children newly diagnosed with
nephrotic syndrome had unsatisfactory knowledge level regarding meaning, causes,
manifestations, investigations, common treatment, and complications of nephrotic
syndrome pre-health instructional program and improved after its implementation by
three months with statistically significant differences. Also, more than one-third of the
studied mothers had an average reported practice level in the pre-health instructional
program increased to nearly two-thirds of them after three months from
implementation of the health instructional program with statistically significant
differences. Conclusion: health instructions program improved effectively knowledge
level and reported practice of mothers' having children newly diagnosed with
nephrotic syndrome. Recommendation: Perform continuous health instructions
program about the nephrotic syndrome is effective especially for the newly diagnosed
cases.