Patients receiving immunosuppressive therapy face many challenges. Medication compliance (adherence) is an important part of the treatment for those patients' well-being.  A high level of compliance to medication regimens can have profound impacts on patients' quality and length of lives, their health outcomes, and overall health care costs. Patients undergoing immunosuppressant therapy were specifically selected to be given online education to protect them from exposure to infection in light of the Corona pandemic. Aim of the study: To examine the effect of online teaching instructions on compliance among patients receiving immunosuppressive therapy. Research design: Pre-posttest quasi-experimental design was utilized. Setting: The study was conducted through online contact (Whats App.). Sample: A convenient sample of 30 male and female patients diagnosed with systemic lupus and multiple sclerosis receiving immunosuppressive therapy. Tools: Data collection tools included a) Personal and Medical data forms and b) Patient Compliance Rating Scale. Results: The study revealed a significant difference between pre and post- instructions. Patients demonstrated a high score level of compliance after applying the online teaching instructions. Conclusion: Providing teaching instructions were very important for improving compliance to the therapeutic regimen. The study concluded that the implementation of the online instructional teaching significantly showed an improvement on the level of compliance among the studied group Recommendations: Improving adherence to the immunosuppressive therapy regimen is necessary for a better prognosis. Developing an instructional program based on issues related to patients' regimens and personal perceptions is highly recommended.