Background: Catheter Associated Urinary tract infection (CAUTI) is one of the most common complications among intensive care patients. Blended learning is a new effective modality applied to improve nurse's performance in critical care units. Aim: the study aims to evaluate the effect of blended training on nurses' performance regarding controlling CAUTI. Design:  The current research design was a quasi-experimental. Setting: The research was performed at Minia University Hospitals in the following intensive care units (ICUs): (Trauma, Stroke, Cardiology, Chest, Urology, and Medical ICUs). Subjects: Purposive sample involved 80 nurses recruited to work in the previously mentioned units. Results: According to the current study, 63.8% of the samples were female and 88.8% of them were between the ages of 20 and 25 years old. Before the blended training was implemented, only 25% of the nurses had satisfactory level of Knowledge about catheter care; after the training, that number had risen to 95%. In terms of practice post implementing the blended training, about 93.8% of nurses reported satisfactory levels regarding catheter care, compared to 22.5% before the implementation of the blended training. Conclusion: Blended training improved the critical care nurses' performance regarding controlling of catheter associated urinary tract infection. Recommendations: Repeating the study on a larger sample and use blended learning for upgrading nurses' performance.