Background: The nursing  job market is undergoing a digital revolution, and those  with the necessary digital experiences and  possess a technology-driven skills will be better positioned to advance in their careers. The study aimed to assess the effect of electronic health records (EHRs) training program via using advanced mobile devices (AMDs) on career success among intern-nurses. Design: A Quasi experimental research design was utilized to conduct this study. Setting: The study was conducted in medical and surgical clinical departments at Benha University Hospital were intern-nurses trained. Subjects: Purposive sample consisted of 60 internــnurses chosen randomly. Tools: To achieve the aim of the cuurent study the following three tools were used; I) Electronic health records EHRs knowledge questionnaire, II) Technological skills observational checklist and III) Career success questionnaire. Result: The study result revealed that 78.3% of study participants had inadequate knowledge related to EHRs in the preprogram phase, which it improved to be 90% & 80% of them had adequate knowledge at immediate post program and follow up program respectively, additionally, 58.3% of intern-nurses had low technological skills at pre-program, which it improved to 76.6% and  83.3% of study subjcts had high technological skills in the post program and follow up  phases respectively,  also 85% & 83.3% of study participants had high level regarding career success in post program and follow up phases respectively compared to 18.3% of them at pre-program phase. Conclusion: The study concluded that there were high significant statistical positive correlations between the study participants' total knowledge and total technological skills toward EHRs and career success throughout program phases. Recommendation: The administrations of health care organizations need to take essential actions to build the appropriate information communication technology ICT infrastructure that needed for the use of EHRs applications in the clinical setting and the progressive implementation of EHRs software program system in the general hospitals.