Background: Intervertebral disc disease is a common chronic condition characterized by the breakdown (degeneration) of one or more of the discs. Chronic low back pain, which is the primary symptom of spinal degenerative illnesses and has a major negative impact on a patient's health-related quality of life (HRQoL), has become more common. Aim: The study aimed to evaluate the effect of a nursing rehabilitation program on the quality of life for patients with the vertebral disk. Design: A quasi-experimental design was applied in this study. Sample: convenience sample was equal to 120 vertebral disk patients. Setting: The outpatient physiotherapy and orthopedic clinics of University Hospital (Beni-Suef, Egypt). Tools: Five tools were used, first tool: was socio-demographic characteristics. Second tool: is the patient's knowledge. Third tool: Numerical pain rating scale. Fourth tool: WHOQOL. Fifth tool: Perceived stress scale. Result: The study showed that 75.8% of studied patients had a good level of knowledge post-program, 0% of studied patients had severe pain post-program, 66.7% of studied patients had a high level of quality of life post-program, and 0.0% of studied patient had a high level of stress at post-program. Conclusion: there was a highly significant positive correlation between knowledge and quality of life of studied patients and also there was a significant negative correlation between their knowledge and stress and pain scores. Recommendation: Conduct research to evaluate the effect of the rehabilitation program on specific types of vertebral disc disease as lumbar disc herniation is recommended.