Context: Successful resuscitation from cardiac arrest results in effective post–cardiac arrest care, which can evolve in the days to weeks after return of sustained circulation. So, electronic learning has grown tremendously and integrated into nursing education and training. Aim: Evaluate the effect of electronic learning package application on nurses' knowledge and practice regarding post cardio pulmonary resuscitation for critically ill neonates. Methods: A quasi-experimental research design was used to conduct the study. Setting: The study was conducted at Neonatal Intensive Care Units of Benha University Hospital at Benha city. Sampling: A convenient sample of (70) nurses working at the above-mentioned settings were included in this study regardless of their personal characteristics. Tools of data collection: Two tools used, Tool 1: A structured interviewing questionnaire designed to assess nurses' personal characteristics, personal data of the studied neonates, and nurses' knowledge regarding post cardio pulmonary resuscitation for critically ill neonates. Tool 2: An observation checklist to assess nurses' practice regarding post cardio pulmonary resuscitation for critically ill neonates. Results:  There was a statistical significant positive correlation between total knowledge scores and total practice scores of the studied nurses post electronic learning package application. Conclusion: It can be concluded that, electronic learning package application had a positive effect on improvement of nurses' knowledge and practice level, which indicates that, the electronic learning package application is greatly effective. Recommendation: The study recommended that, An update electronic learning and training programs should be periodically conducted with numerous teaching methods for staff nurses in NICUs to improve their performance regarding post Cardio Pulmonary resuscitation.