Background: Cochlear implants help children with severe hearing loss receive, process, and interpret sounds. Hearing loss can affect these areas of development. Aim of the study was to evaluate the effect of educational program on mothers' empowerment and satisfaction regarding caring of children post cochlear implant. Research Design: A quasi- experimental research design was used. Setting: This study was conducted in Department of Cochlear Implants and Audiology in Bahteem Health Insurance Hospital at Qalyubia governorate affiliated to the ministry of health and population. Subjects: Purposive sample of (80) mothers and their children. The total number of mothers was divided randomly into two identical groups. Tools of data collection: Four tools were utilized, Tool (I): A Structured Interviewing Questionnaire. Tool (II): Pediatric Cochlear implant questionnaire. Tool (III): Satisfaction with life scale. Tool (IV): Mother' empowerment scale. Results: the results of the present study revealed that there were highly significant differences in mothers' knowledge, reported practice and their satisfaction and empowerment after educational program implementation P <0.001. Conclusion: The study concluded that, educational guidelines significantly improved mothers' knowledge, practice, empowerment and satisfaction regarding caring of their children with cochlear implant. Recommendation: Developing and enhancing educational and awareness program to improve and support mothers' empowerment and satisfaction regarding caring of their children with cochlear implant