Purpose: The study aimed to investigate the association between perceived social support and 
psychosocial adjustment of geriatric cancer patients undergoing chemotherapy. Methods: Two hundred 
geriatric patients provided consent were interviewed and the data collected using the Psychosocial 
Adjustment to Illness Scale (PAIS), the Multidimensional Scale of Perceived Social Support (MSPSS), 
In addition to demographic and clinical data. Data was collected from Kasr Al-Aini Center for Oncology 
and Nuclear Medicine, Cairo, Egypt after the study protocol was approved (Approval No. 10), August 
2019. Correlations using Pearson and Spearman coefficients as well as binary logistic regression were 
used using The IBM SPSS software package, version 26. Results: The psychological distress domain 
was found to have the highest mean score (14.2±4.5) among the psychosocial adjustment domains, 
whereas extended family relations were found to have the lowest mean score 6.8 ± 2.09. The study also 
found that there was a significant negative correlation between the overall scores of the psychosocial 
adjustment scale and the multidimensional scale of perceived social support (p <0.001). Moreover, a 
significant negative correlation between the overall scores of the Multidimensional Scale of Perceived 
Social Support and the following sub- domains of the Psychosocial Adjustment Scale: health care 
orientation, extended family relations, and psychological distress (p <0.001) was detected. Those with 
high level of perceived social support were 0.044 times more likely to have high psychosocial 
adjustment compared to those with low level of perceived social support (p<0.001). Females were twice 
less likely to have high psychosocial adjustments compared to the males. Conclusion: Our findings 
indicate that there is an association between perceived social support and elderly' psychosocial 
adjustment. In addition, perceived social support is found to be an independent predictor of psychosocial 
adjustment. Therefore, establishing or strengthening the existing social structures throughout the 
treatment journey is recommended for elderly cancer patients.