Background: peptic ulcer has a major impact on the health status and continues to be a considerable cause of morbidity and mortality among elderly people. The aim of this study is to assess quality of life among elderly people with peptic ulcer at geriatric home. Design: descriptive study design was used. Setting: The study was conducted at 3 geriatric homes in the Fayoum Governorate and Cairo Governorate. Sample: purposive sample was used; they were 60 elderly people aged 60 years old and more of both genders. Tool: The tool consists of 4 parts: 1st part, demographic characteristics of elderly people. 2nd part is the medical history of elderly people related peptic ulcer. 3rd part, elderly people knowledge regarding peptic ulcer. 4th part, quality of life scale to assess the effect of peptic ulcer on quality of life among the elderly people. Results: The study results showed that 32.2 % of elderly people were aged 70 to less than 80 years old, 50.8 % of them were female, and 54.2% of elderly people were widowed. Regarding level of education 44.1%of them had primary education and 42.4% of them were illiterate, also 83.1 % of elderly people lived in urban areas and 39% of elderly people had a job. Regarding medical history 66.1% of elderly people were nonsmokers, 55.9%of them suffered from gastric ulcer. Additionally, 39% of them had family history of peptic ulcer previously, 45 % of them had epigastric pain. In relation to knowledge 79% of the elderly people had poor knowledge about peptic ulcer, and 91.5% of them had poor quality of life. Conclusion: it was concluded that; there was statistically significant relation between gender, marital status of the studied elderly people and their total knowledge about peptic ulcer and there was no statistically significant difference between other demographic characteristics of the studied elderly people and their quality of life, also there was statistically insignificant relation difference between total knowledge of the studied elderly people and their total quality of Life. Recommendations: Health educational program should be developed and implemented for elderly people with peptic ulcer to improve and update them with the most current information about the disease, practices, and quality of life.