Background: Toxic leadership is ineffective conduct that embodies the bad or dark side of leadership and has the ability to negatively impact not only the followers but the entire hospital. Aim of the study: To explore the relation between toxic leadership, nurses' passion for work and organizational agility.  Design: A descriptive correlational research design was used. Setting: This study was applied at (Minia University Hospital as well as Mental Health and Addiction Treatment Hospital), at Minia city, Egypt. Subject: A convenience sample included all nurses who were working at the previously mentioned hospitals (n= 260). Tools of data collection: three tools were used, tool I: Toxic Leadership Scale, tool II: passion scale, and tool III: organizational agility scale. Results: illustrated that (51.6%) of nurses perceive their head nurses as high level of toxic leadership, (67.7%) of nurses had moderate level of passion for work, and there was (77.3%) of nurses reported that the organizational agility level is moderate. Conclusion: there was a negative significant correlation between toxic leadership and nurses' passion for work as well as organizational agility.  However, there is a positive significant correlation between nurses' passion for work and organizational agility. Recommendation: nursing leaders should be provided with the necessary leadership skills and practices to fulfill their responsibilities toward nurses and improve job outcomes by establishing leadership training programs.