Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a lifestyle-related disorder with a significant global public health concern. Healthy lifestyle changes like dietary adjustments, consistent physical exercise, and gradual weight loss are the ideal strategies which applied together to manage the disease. Aim: to investigate the effect of a diversified program on lifestyle modification among obese patients with non-alcoholic fatty liver disease. Research Design: A quasi-experimental research design (pre-posttest) was utilized to achieve the aim of the study. Setting: The study was conducted at the internal medicine outpatient clinics of Menoufia University Hospital in Menoufia Governorate, Egypt. Sample: A purposive sample of 104 adult male and female obese patients with a confirmed diagnosis of NAFLD was selected. Tools: Four tools were utilized to collect data: (I) Personal and Medical Data Form, (2) Patient Knowledge Assessment Questionnaire, (3) Physical Activity Assessment Form, and (4) Lifestyle Modification Assessment Questionnaire. Results: All research hypotheses were supported; statistical significant differences were found between the pre and post intervention in relation to knowledge level, physical activity as well as lifestyle modification. Conclusion: Diversified program has a significant positive effect post intervention on obese patients with NAFLD. Recommendation: Implementing the diversified program on a larger probability sample is recommended.