Background: Multiple Sclerosis (MS) is a chronic disease occurred in the central nervous system which may be developed under 18 years old. Children with MS have lower Quality of Life (QoL) compared with other chronically ill patients. Health Belief Model (HBM) used to perceive and predict promotion for coping patterns and QoL practices. Aim: The aim was to evaluate the effect of implementing educational intervention program, which based on HBM regarding coping patterns and QoL among children with MS disease. Research design: A quasi-experimental design was utilized. Sampling: A purposive sample involved 50 children suffering from MS. Setting: MS outpatient clinics in Medical Psychiatric Center, Ain Shams University Hospital. Tools:  Data collected through using the following tools (pre/post) including an interviewing questionnaire, Jalowiec and Power's Coping Scale, Stress Tolerance Test, and Pediatrics Quality of Life Inventory Fourth Version (PedsQL4.0) for MS. Results: After implementing the educational intervention program based on HBM, most of the studied children had satisfactory level of knowledge regarding MS disease, as well most of them had positive total coping patterns. In addition, the majority of children had high stress tolerance and good total QoL. Conclusion: Educational intervention program based on HBM had a positive effect on children with MS disease in relation to improving their knowledge, enhancing coping patterns and improving stress tolerance and promoting their QoL. There were positive correlations between the total levels of studied children knowledge, coping patterns, stress tolerance and QoL pre and post the program.  Recommendations: Further studies needed to assess factors affecting QoL among children with MS, and using health belief model in planning of health-centered interventions based on empowerment of children with MS in self-care activities.