Background: Proximal humeral fractures are the third most common fractures, following hip and distal radius fractures. Patients suffering fractures in overwhelmed hospitals have serious difficulties restoring their pre-fracture function. Aim: To investigate the impact of an awareness program on pain, fatigue, and shoulder function among patients post-humeral fracture surgery. Research design: A quasi-experimental research design was used to achieve the aim of this study. Setting: The study was conducted in the orthopedic outpatient clinic at Mansoura University Hospital. Sample: A convenient sample of 100 patients collected during six months aged (20-65) years old and from both sexes with proximal humeral fractures were included in the current study within six months. Tools: I: Structured interview questionnaire, II: Visual Analogue Scale, Tool III, Fatigue assessment scale, and IV: Shoulder function index. Results: There was a statistically significant difference in the total mean score of the knowledge, practices, pain, fatigue, and shoulder function after the awareness program application among patients post-humeral fracture surgery. Conclusion: The application of an awareness program has a positive effect on enhancing knowledge and practices, and reducing pain and fatigue. Also, improving shoulder function among patients post humeral fracture surgery. Recommendations: Awareness programs are recommended to be an integral part of the preoperative nursing teaching for patients undergoing humeral fracture surgery.