Background: Numerous reasons, including growing diseases, technology advancements, and epidemiological changes, have contributed to the recent increased the demand for healthcare services. The health care demands are always changing, and staff nurses' everyday job is greatly impacted by legislative actions, system changes, and reduced funding. Aim: This research aimed to assess the relation between job demands, stress and burnout among nursing staff regarding their knowledge about climate changes. Design: Descriptive correlative design was adopted to achieve the current study aim. Setting: the research carried out in two hospitals and four MCHs Centers located at Minia City – Minia Governorate, Egypt. Subjects: Convenience sample including all nurses (n=392) who share in data collection and who were on duty employed in afforded work settings. Research Tools: Four tools were utilized for data collection; I. Nurses Knowledge about Climate Changes, II. Copenhagen Psychosocial Questionnaire, III. The Perceived Stress Scale and IV. Maslach Burnout Inventory-Human Services Survey. Results: more than fifty percent of nurses had "fair" level of total knowledge about climate changes as well as most of them had "high" grade regarding their job demands. Also, more than half of the nurses perceived "moderate" work stress level, while above fifty percent expressed "high" level of burnout. Statistically significant positive correlations were existed between the degree of job demands, work stress and burnout, while no statistical relation were found between total knowledge about climate changes and any of other study variables. Conclusion: Nursing staff frequently overwhelming with excessive job demands. Recommendations: Activities reducing stress and burnout should be carried out by nursing staff.  Nurses should participate in seminars and in-service training about climate change.