Background: Elderly stroke survivors face great challenges namely living with disabilities which require long term support. In such situation, family involvement in care process is inevitable. Family centered empowerment program enhance patients' motivation to achieve optimum outcomes. Aim:  This research aimed to determine the effect of family centered empowerment program on self efficacy, depression and quality of life in geriatric patients with ischemic stroke. Design: A Quasi-experimental research design was used. Setting: The study was conducted in the rehabilitation department at Mansoura University Hospital. Subjects: A total of 108 geriatric patients with ischemic stroke were included in the study and randomly assigned to two equal groups; the intervention group received the family centered empowerment program plus the routine care in the rehabilitation department, and the control group received only the routine care provided in the study setting.  Tools: The data were collected through demographic and health related characteristics interview sheet, stroke self efficacy questionnaire, stroke-related knowledge, geriatric depression scale and stroke impact scale. Results:  Study findings showed that the study outcomes including self efficacy, stroke-related knowledge, post stroke depression and quality of life were significantly better in the intervention group compared with the control group (p<0.001). Conclusion: Implementation of the intervention based on family centered empowerment model is an effective strategy in improving self efficacy, depression level and quality of life among geriatric patients with ischemic stroke by giving them necessary information about caring principles with family involvement in care process.  For such patients, this model is recommended to use in the educational program.