Background: Even though a person's sexual well-being is an indicator of general health. Still largely ignored in Eastern societies like those of Egypt, and particularly Upper Egypt, female circumcision is one of the most frequent health issues that have a considerable detrimental influence on a woman's sexual function. Aim of the study: to evaluate the effect of PLISSIT model on female sexual dysfunction and sexual quality of life among married circumcised women at Minia governorate. Subjects and Methods: Quasi- experimental design (pre-post study) was conducted at outpatient obstetrics and Gynecology clinics at Minia university hospital for maternity and children. A purposive sample of One hundred and twenty five married circumcised women was included in this study. Data was collected through three main tools structured interviewing questionnaire, Female Sexual Function Index and Female Sexual Quality of Life Questionnaire In addition to, a supportive material (guidelines) was distributed to the studied women. Results: The current study clarified that, the mean age of circumcised women was 27.6 ±3.5years, there was a highly statistically significance difference related to the Female sexual function International Index of Erectile Function and Female sexual quality of life scores at pre-post intervention and follow up of the intervention(PLISSIT model) at (P-Value <0.001). Conclusion: Implementation of sexual guidance premised on PLISSIT model had a significant effect in improving the sexual function and sexual quality of life among circumcised women. Recommendation: More research is required to fully understand how female genital mutilation affects women's physical, mental, and social health. In addition, Verification of the PLISSIT model on a variety of women complaining of dysfunction in outpatient clinics and educational guidelines should include information on how to handle circumcision-related sexual difficulties.