Background: Burned patients faced multiple challenges, complications, and adverse effects, a transitional burns rehabilitation program guided by nurses was developed to enhance the overall health status of burn patients by improving their psychological well-being and quality of life.. Aim: Evaluate the effect of nurse-led transitional burn rehabilitation program on a comprehensive health status for patients with burn. Design:  The research design was quasi-experimental. Subjects: Fifty burned patients in a purposeful sampling.  Setting: The study was carried out in Mansoura University Burn Center & Mansoura Governmental International Hospital's outpatient burn clinic. Data collection tools: five tools utilized in this study;  Tool I. structured interviewing questionnaire of demographic characteristics and clinical  data of  studied patients , tool II: Burn Specific Health Scale-B (BSHS-B), tool III: The Burn Depression Checklist, tool VI: The Burns Anxiety Checklist, and tool V: Pittsburgh Sleep Quality Index (PSQI).Results: majority of burned patients (94%) had good quality of health at follow up phase in contrast to the pre-intervention program   . It revealed additionally, that differences were statistically significant (χ2 =136.893, P=0.000). Additionally, It illustrated improvement in BSHS-B after the post and follow-up interventions with Estimated marginal means (69.92, 102.88) respectively compared to pre-intervention (38.92).Conclusion: The transient The brief rehabilitation program has a positive clinical influence on the participants' life quality and enhances  comprehensive health status of burn patients. Recommendations: An extension of this research with a larger probability sample from other regions to help make the conclusions more broadly applicable.