Background: Understanding Congenital Heart diseases is crucial for pediatric nurses as they play a significant role in saving a child's life. Concept maps serve as effective tools to assist nurses in easily recalling these important topics, thereby aiding in informed clinical decisions for the patient's condition. Aim: To evaluate the effect of the concept mapping program on pediatric nurses' satisfaction and knowledge acquisition regarding congenital heart diseases. Design: A quasi-experimental study. Settings: The study was conducted in the neonatal intensive care unit, pediatric intensive care unit, and pediatric ward at Suez Canal University Hospitals. Sampling: A convenience sampling method was employed, consisting of 48 pediatric nurses in the pre-test group and 46 nurses in the post-test group. Instruments: Three instruments were employed for data collection in the study: a knowledge assessment questionnaire on concept mapping, a knowledge assessment questionnaire on congenital heart diseases, and a nurses' satisfaction questionnaire. Results: The total mean score for nurses' knowledge about concept maps and congenital heart diseases after implementing the program showed a statistically significant improvement (p<0.01). Additionally, nurses expressed high satisfaction with the training program (mean score 48.22 ± 1.89). Conclusion: The study offers evidence that the effective use of concept mapping training improves pediatric nurses' understanding of congenital heart diseases and enhances their satisfaction with the implemented program. Recommendation: Adoption of concept mapping as an educational strategy for delivering various training programs that hold significant importance for pediatric nurses, including those related to respiratory, renal, neurological, or congenital diseases.