Background: Professional accountability (PA) a critical behavior that supports consistency between nursing actions and standards associated with patient care quality and safety. Nurses need to focus on the behaviors that lead to the growth and development of PA. One of these behaviors is emotional quotient (EQ). EQ has been described as an array of emotional, personal, and social abilities and skills that influence one's overall emotional perception. Aim: This research aimed to explore the relationship between perceived nurses' professional accountability and their emotional quotient. Develop a complete structure equation model between professional accountability and their emotional quotient and its related dimension. Design: A descriptive correlational design was utilized in the study. Setting: The study was conducted in medical, surgical, and critical care units at Damanhour National Medical Institute. It is affiliated with General Organization for Teaching Hospitals and Institutions. Tools: Two questionnaires were used in this empirical study, namely, Burns Professional Accountability Instrument and Genos Emotional Intelligence Concise Inventory. Participants: 260 nurses out of 385 nurses in the pre mentioned; A convenience sampling method was used to select the study participants. Result: EQ was shown to be positively correlated with PA (r=.910*, p value=.012). Conclusion: In light of the main study findings, it was concluded that there were positive correlation between EQ and PA and its related dimension. The studied nurses perceived high level of total PA and got the highest level of EQ and its related dimensions. Recommendations: developing a positive workplace environment with unambiguous managerial support is essential for equipping staff with the knowledge and abilities necessary for them to recognize, make use of, and promote their levels of PA and EQ in this special type of work setting